by Jes Williams @feelmoregooder
What is Resveratrol?
Resveratrol (isolated initially from Veratrum grandiflorum)(5) is a naturally occurring polyphenol (polyphenols are beneficial plant compounds) that possesses a wide range of potent health-boosting properties - which may be harnessed in strategies against chronic diseases. (1)
History of Resveratrol
We see resveratrol pop up in science when scientists were studying what’s referred to as the French Paradox. “The French paradox is the observation of low coronary heart disease (CHD) death rates despite high intake of dietary cholesterol and saturated fat. The French paradox concept was formulated by French epidemiologists in the 1980s.” (11)
Research following that in the 1990’s, done on both and mice, demonstrated that resveratrol offers significant antioxidant and anti-inflammatory properties. Because of this, more studies began to roll out to further examine this promising plant constituent. (12, 13, 14)
Since that time, the “French Paradox” has been disproven. However, the interest that was peaked around resveratrol is absoluetly valid. Researcher David Sinclair out of Harvard University shows us this, as he has conducted some remarkable research on resveratrol’s anti-aging benefits through a particular pathway called SIRT1. (15)
Mechanisms of How Resveratrol Works
Resveratrol belongs to the polyphenol stilbenoids group, which possess two phenol rings linked to each other by an ethylene bridge.
Some molecular mechanism of resveratrol action include:
- -Inhibition of prohypertrophic signaling molecules
- -Improvement of myocardial Ca2+ handling
- -Phosphorylation of prosurvival (Akt-1, GSK-3β)
- -Enhanced stress signaling (MKP-1) pathways
- -Reduction of oxidative stress and inflammation (iNOS, COX-2 activity, and ROS formation)
-Significantly reduced blood glucose, body weight, plasma triglyceride levels, and heart rate (2)
What Foods Contain Resveratrol?
The main food & plant sources of resveratrol include grapes, many berries, peanuts, soy, medicinal plants such as Japanese knotweed, and red wine.
What are the Benefits of Resveratrol?
Studies show us that this mighty polyphenol resveratrol offers the body a range of potential health benefits, including:
- -Improving cardiovascular health by reducing inflammation and oxidative stress
- -Aiding the vascular system
- -Supporting the kidneys and renal function
- -Regulating cell signaling pathways to inhibit dysfunction and promote normal cellular activity
- -Activating a group of proteins called sirtuins (which are responsible for proper cellular functions)
- -Fighting ailments related to abnormal cell growth
- -Promoting apoptosis
- -Regulating blood sugar levels
- -Protecting against neurodegenerative diseases
- -Aiding the body through antioxidant properties
- -Defends against viral organisms
- -Controlling oxidative stress
- -Mimmicking the beneficial effects of calorie restriction
- -Protecting against chronic inflammation
- -Inhibiting fat accumulation
(1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Things To Know About ResverElite
When supplementing with ResverElite, we recommend a dose of 2 capsules per day. You can take both capsules at once, however, we recommend that you take one in the morning and one in the evening.
You may wonder, what makes our product unique? Well - as is the case with the plant polyphenols berberine, quercetin, and curcumin, the resveratrol compound is not bioavailable. Thus, less than 1% of what you ingest will pass through your gut wall barrier. Here at the Mara Labs, we have solved this problem by attaching the resveratrol in ResverElite to a novel, organic carrier molecule making it highly bioavailable.
References:
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https://www.sciencedirect.com/science/article/pii/S0753332221009483
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https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.1064507/full
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https://pubmed.ncbi.nlm.nih.gov/?term=david+sinclair+resveratrol
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