Bioavailability vs Functionality of a Supplement



In this video, Dr. Martin Katz and Dr. John Gildea touch on the importance of a supplement's bioavailability (does it get into the blood stream) and functionality (does it make the desired impact).


Martin Katz (00:10):

Hi, I'm Martin Katz, family physician, sports medicine physician, incredibly invested in wellness and lifestyle, and certainly prevention for you and yours. I'm joined with John Gildea today, research scientist [trained at] Johns Hopkins. And we're going to answer a very important question today about bioavailability. So if you take a supplement, is it going to work for you? Is it going to get to where it needs to go? So this brings into question this idea of bioavailability, but possibly, and probably more importantly, functionality. So not only is it getting into the bloodstream, but is it working? And if it is, is there some sort of ceiling as to how much you need to take for it to get there? So, John, do you mind answering maybe the bioavailability question?

John Gildea (00:56):

Yeah. So I mean, I think about this issue all the time, because there's so many supplements that the first question is, does it have the molecule in the pill? We answer that all the time, and we measure every batch that we get. Yes, it's there. The second thing is how does it get into the bloodstream? Sulforaphane happens to be very bioavailable, so most of it gets into the bloodstream. That's really important. And all the clinical studies that are being tested, the circulating concentration of sulforaphane varies very little, even though the doses that you're ingesting is a lot. And then that tells me that yes, it gets into the bloodstream very well. It also tells me that it leaves the bloodstream really well. And that's where sulforaphane does its function. It has to leave the bloodstream and go to the cell.

John Gildea (01:48):

So when a supplement makes it to the cell, it has the chance of getting into that cell and affecting the pathways that we want to test. And we do test that, and we know that the amount of sulforaphane that is in our pill is functioning at a higher level than just straight sulforaphane. We've shown that many times. And it's because there are numerous molecules in there that work together to affect function. So in order to test that, you have to actually test a cell in a person. And we've done that in two different ways and show them that the amount of isothiocyanate that's in our product is equivalent to two to five times as much of pure sulforaphane. And that's the synergy that we're going after all the time, that they functionally work together to get to the cell to affect function.

Martin Katz (02:44):

Yeah, so there you have it. We have created this molecule, stabilized sulforaphane. It's important to understand we went after the stabilized form so we knew that that was going to get into the system and create this bioavailability. And then the stabilized form of sulforaphane creates the functionality with these cousin molecules, again, that are making our form, BrocElite, three to five times more potent than we'd say the next closest competitor. So again, if you want more information, please click on the link below and visit our website. Thank you.



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