David Roberts and Drs. John Gildea and Martin Katz discuss Mara Labs' new menopause product, MenoMize, highlighting its ingredients: black cohosh, carnosic acid, and resveratrol. Black cohosh stabilizes the hypothalamus, aiding sleep and mood. Resveratrol, a selective estrogen receptor modulator, benefits cardiovascular health and sleep. Carnosic acid activates NRF2, inhibits NF-kB, and stimulates AMPK, promoting detox and antioxidant responses. The product is suitable for both perimenopausal and menopausal women, and it can be taken long-term. They emphasized the importance of personalized medicine, taking into account factors such as hormone-binding globulin and genetic predispositions.
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David Roberts 0:10
Hello everybody. David Roberts here, and I am not on the camera, but we do have Dr John Gildea and Dr Martin Katz here, and we're excited to be talking to you today about our new menopause product that's going to be released this week. And so without further ado, we just want to thank you for your time. Thanks for joining us, and I'm going to hand it over to these gentlemen to get going.
Dr. Martin Katz 0:39
Hi everybody. So we're here to discuss a topic that doesn't get enough time, certainly not in medical school, certainly not through residency. For most of us and even in the science literature, we are starting to see more and more studies that are performed, and more and more data points that we can look at. It is a fairly complex pathway, to say the least. I think we've known women are complex for quite some time, and this is certainly an area where that complexity is shown. We are looking at those pathways today. We are going to try and discuss a balance as to try and help you learn why it is that you may be menopausal, or why you want to avoid going down that pathway in the first place. This topic is is quite a good balance, or an exceptionally good balance in the holistic world of medicine, where you truly can use lifestyle to help limit the effects of a decreasing progesterone, initially decreasing estrogen, change in the type of estrogen and a decreasing testosterone. Through lifestyle, you can support it through supplements, which is what we're going to talk about today. And then for those who are maybe premature, having significant symptoms and need a life raft, there are certainly medications that can go a long way to help. So we'll attempt to do our best to go through this one step at a time with David sort of driving the conversation, and hopefully you'll leave with having a keen sense of what you need to do to minimize your symptoms and feel better through perimenopause, menopause. And you know, have a great I guess, second part of your life after childbirth. And I guess, as men, just as as well as men, sort of losing our biologic relevance, but still wanting to be young and healthy.
David Roberts 2:47
And apologies in advance for the the poor video. We are recording this with another video camera. Oh, John, would you mind clapping so we have a time sink? All right? Thank you. Can I clap too?
Dr. Martin Katz 3:00
I want to clap. Clapping
David Roberts 3:06
is fun. Yes, okay,
Dr. Martin Katz 3:09
how's the audio? Yeah, fantastic.
David Roberts 3:15
All right, so, how about we just so we have the product. It has black cohosh, carnostic acid and our form of bio available resveratrol in it called resvera elite. Why don't we just go blow by blow to start off with, and talk through why we have those in there.
Dr. Martin Katz 3:38
We'll let we'll let John lead that thing. He came down on those pathways and figured out what best. And again, very complex. So we've spent a lot of time trying to figure out which supplement and which phytonutrient would be best. And so thank you, John for doing that. Yeah.
Dr. John Gildea 3:53
So it sort of came down to me as a balance between the short term effects, like right when you go into perimenopause, you feel a lot of changes that happened right away. And so we wanted to block some of the bigger ones in that at first, which basically comes from brain related things, the hypothalamus seems to be the central feature for a lot of the immediate effects when you enter perimenopause. And so that is neuroendocrine disruption. And so that's probably a good place to start with. It is that black cohosh being a triterpreide, it goes to the brain, stabilizes that neuroendocrine sensing center in your hypothalamus, so helps with the sleep. It helps with the night sweats and mood that often comes along with the beginning of perimenopause. And so those are that's been studied in pretty large. Uh, cohort studies, 400 and have done, done safety studies at the same time out to two years, very cleanly, where the big worry that a lot of people have, if you have, if you're if you're blocking estrogen related effects, whether you're actually stimulating estrogen receptor alpha. And the nice part about that is that's very cleanly not activating the ER Alpha receptor. And so we're not getting into that whole world of of the phytoestrogens that are estrogen mimics, so maybe controversial in 2003 when the first papers came out. But a lot of the issues that you may run into if you if you did a search on that compound, is that is some of the side effects that people have had are most likely attributable to not perfectly isolated extracts. And so the background, side effects from negative side effects from it are very they're not higher than placebo. So that's a good place to start.
Dr. Martin Katz 6:17
Just a little background on that. Perimenopause is, interestingly, a decrease in progesterone first. And if you remember from pregnancy, after hopefully getting over the nausea and vomiting, it's should be a time of happiness and joy, and progesterone does provide some of that. And again, when you're pregnant, progesterone is elevated. It's good for immunity. It's good for a lot of things. And so early in perimenopause, you get this estrogen dominance, and estrogen is sort of all over the place, so a lot of women do feel quite anxious. And again, it also depends on what neural pathway or what receptor you're activating, and also which part of estrogen you are breaking down. So that gets, that's where we get very complicated. And again, through the show, we may get into some of that. But just the background here is, initially, we have a, we have an estrogen dominance in early perimenopause, so more anxiety, possibly breast tenderness, mood swings, irregular menses, because you don't have progesterone stabilizing that the estrogen line or the endometrial lining, excuse me. And so you get irregular menses. And so again, we want to sort of help manage those symptoms, both through the receptor and how we're breaking down estrogen more cleanly.
Dr. John Gildea 7:46
Yeah, so it's it's at least in the initial phases that seems to dampen down some of the noise, the overshoot, the counter, regulation that's going on, and some of that from what you're saying, and ovulation, beginning, beginning phases where you're starting to not do your cycle perfectly, and that's the progestion, or an angle. So yeah, and then so to switch over to the next supplement in there is Rivera trial. So just
David Roberts 8:15
to recap, black cohosh in two sentences.
Dr. John Gildea 8:20
Brain effects of lack of estrogen is stabilized with a brain specific tower down supplement stabilizing your brain, brain relation of to neuro endocrine,
David Roberts 8:37
okay. So resveratrol, yep.
Dr. John Gildea 8:40
So resveratrol very interesting in that it's a selective estrogen receptor activator, so it's er beta agonist. So a lot of people don't know that, even in men, if you can stimulate that er beta signal, it's good for you, good for a lot of different things, prostate for cardiovascular health for sure. And so we have a particular version of resveratrol where you get it past the enterocytes using our patent pending novel carrier molecule. And then, as well, we have a way of increasing the circulation time for for the molecule. And so that one two punch really makes it stand out as a as something that can modulate every part of your body, whereas normally a big part of the resveratrol effects are likely local in your in your digestive tract, so getting it past there really makes it possible to get to other cells. And so for that second part there, your beta agonist activation is really great for some of those new. Own side effects of entering full menopause, difficulty sleeping. We can put waking up in the middle of night. There's, you know, a whole host of things where, if you can, if you can stimulate er beta is really super beneficial. And so that would be kind of the summary of er beta, you have any extra to add there? Yeah.
Dr. Martin Katz 10:24
I mean, those are the sort of more neural receptors. And then you have also on the cell, cell membrane, you have other receptors. And again, these, these molecules, are working well to help that balance. The other thing about, again, progesterone going down, estrogen elevated, not always in the right forms, is some of these molecules are helping balance that. And then there's this other molecule, which, again, woman in their daily activities, being the primary person, nurturing the family, getting everybody together. You know, my clinical experience women are dealing with a full grown husband who may need some help, myself included, and then, and then children who certainly need some organizing. And they're working and they're cooking, and it's, it's a lot, and there's, you know, fair amount of cortisol involved, which can also then steal from progesterone and have an effect on on this your alpha beta ratio and what's happening there. So any help that that you can get, again, from from supplements, is ideal, but again, regulating your stress incredibly important. So two higher cortisol, steel to lower cortisol adds to sort of what's happening with with symptoms of anxiety and fatigue and just not feeling up to par. So again, it's, it's a it's, it's a balance, and very much a holistic approach to what's happening at the cellular level, the membrane, and then within the within the cell, going to the the, you know, the genes, yeah.
Dr. John Gildea 12:10
So cert, cert, one activation. That reminds me that resveratrol is probably the right. Cert, one activation. So that's the genomic stability component of it. Yeah. Thanks for bringing that up. That's super important. It also is a connection to mitochondrial health, which is the PGC one Alpha. It activates that quite well. And then recently, we've been talking a lot about the fact that it's cert one is the histone deacetylate That that stimulates tfeb, which is the making really good lysosomes for clearance, autophagy and clearance. So, yeah, it's really, really great molecule to get in the middle of the things that are happening during female maturation. And so maybe switch to the last one. And this one probably is one that's not as well known. But I've been gaining a fondness for this molecule for quite a while, and we're, we're really happy to find a super high source, source of very clean version of this. And so we could put it in, in this in this product, and, and so carnostic acid is, that's carnostic acid, right? Carnostic acid is has this incredible triumvirate of of targets. And you've heard us talk a lot about NRF two, well, so carnostic acid activates NRF two, we've heard you've heard us talk about NF kappa b in terms of inflammation, so it inhibits NF kappa B. And then also you've heard us talk about amp kinase stimulation, which is fasting mimic and so it activates amp kinase. So it's not the best version of all three of those, we already have three of the very best of those, but to get into one pill, it's really helpful, in this case, to have this wide, wide effect of stimulating detox, stimulating all The antioxidant response. Element driven genes that are, are antioxidant enzymes, detox So,
Dr. Martin Katz 14:26
and then it's also more bioavailable. So you don't need this one pill with just chronosic acid, exactly.
Dr. John Gildea 14:32
Yeah, it's quite, quite bioavailable. And, and so this is a great, great thing to combine with those other two to get very wide coverage.
Dr. Martin Katz 14:42
And by the way, it comes from rose Mara. So hopefully you're doing some of your rosemary in your foods. Again, we're we're getting to buy availability here. So, but again, another amazing molecule from food, yeah.
Dr. John Gildea 14:54
And just like with our broccoli product, we're always saying, make sure you eat your broccoli as well. Or even take sprouts. This is the same is, this is one particular molecule from rosemary. So you get with the with the actual Rosemary as a herb, and there's some synergies built into that, into that, yeah.
Dr. Martin Katz 15:16
So, as often told my patients, probably bang for the buck. I'd say herbs and spices are probably the thing we should be adding the most to our food. They're just power packed and not very filling. You can put a bunch on it makes the food taste better. You can experiment and have, you know, nights where you're eating more ethnicity towards, you know, Latin America, Asia, Europe, Middle East, and have a lot of fun with that. And these herbs and spices really add to that flavor.
Dr. John Gildea 15:47
Yeah, so when you're talking about your eat your eat your vegetables, that's the one of the go tos you do is make sure they're not just boiled and bland. For your first experience,
Dr. Martin Katz 15:59
we wonder why kids don't enjoy vegetables because they're eating steamed broccoli with nothing else.
Dr. John Gildea 16:07
But yeah, that's one of those amazing molecules. Rosemary has our solid acid and Rose Mara Nick acid in there. So there's, there's a number of other compounds in there that are very beneficial.
Dr. Martin Katz 16:21
Sounds good. David, do you want to steer us in a direction from here? So we have a
David Roberts 16:26
question that's come in. I'm going to text you the there's question about a supplement. If that, if they take our supplement, do they? Can they stop taking this other one. So why don't you just look at it real quick?
Dr. Martin Katz 16:44
You're texting it to us. Yeah, okay, you don't want to just tell us the question,
David Roberts 16:49
no, because it's you have to look at the supplement facts. Okay, interesting. So it is
Dr. Martin Katz 17:00
a ortho molecular product, yeah, I mean, I think there's, you know, arguably, many ways to skin this cat,
David Roberts 17:07
estrogen, SEPTA beta supplement, basically,
Dr. John Gildea 17:17
I don't know that particular compound.
Dr. Martin Katz 17:20
I'm not familiar with that one either. I would take some studying. So basically, like rhubarb.
David Roberts 17:31
So, so which, which one of our, of the three, is the estrogen
beta, yeah, resveratrol, resveratrol.
So that's probably as good or better.
Dr. John Gildea 17:47
Well, it's not just an ER beta agonist. It's it's a cert one activator. So whether you believe all the studies out there, whether it's, you know, longevity molecule, but it certainly is activating cert one, which is a genomic stability compound, very good for you, and it, it is the best cert one activator out there. There's a lot of pharma company companies going after novel molecules that activate cert one. And just to put a little exclamation point on that, with all the controversy that's out there, one of the controversies is whether it activates cert one, and I think the that has been completely put to rest in that in human cells, they added resveratrol, saw very clear cert one dependent response, and then knocked out cert one and saw no, no, no response. And so it was a good way to do a study. Close as you can get to how you define a driver gene. You know, if you have the mediators and modulators, we always talk about that in the pathway literature, is a mediator is defined as if, if you have a phenotype from something, a knockout, and you can, you can replace that gene that's the mediator of that of that pathway, that's how model organisms do all of their studies. And in the case of of cert one and resveratrol, that's locked in tight.
David Roberts 19:19
So second question, how does this project change hormone signaling? Is it similar to maca, M, A, C, A, and what age is best to start the product?
Dr. Martin Katz 19:31
Yeah, I think the literature is getting more and more clear on on the earlier you start, the better. Certainly in primary ovarian failure, you want to start those people very try and identify them. Unfortunately, the the time of symptoms to diagnosis can be quite some time, because, you know, they their symptoms are blamed on many other things, including, you know, anxiety, depression, etc, but primary ovarian. Failure you want to get that early, but fortunately, that's not very common, but, but again, in people having perimenopause, addressing those symptoms early, rather than later, can be quite helpful. And this is somewhat of a genetic thing, so you you know understanding when your mother went through it your sisters can be quite helpful in understanding when you may go through it, your severity of PMS can also be a, another sort of hint as to how you're going to do, how you did with your your early pregnancy can be another, another hint so and how hard it was to get pregnant. So these things can sort of guide you. And again, starting earlier rather than later, has been shown to be quite beneficial, and that that includes the lifestyle changes. So limiting alcohol, limiting stress, again, for that cortisol approach, increasing exercise, and again, I think hopefully you've heard it by now, but for so many years, women were were very much into the aerobic side of things, doing a lot of aerobic activity. But it's quite clear now we should also be encouraging our female patients and and women allies to be doing more resistance and ensuring adequate protein, ensuring adequate sleep, hydration, all these things are imperative, and then again, starting this perimenopausal thing at the onset of symptoms.
Dr. John Gildea 21:32
So I guess I'll answer the signaling, direct signaling thing, Mucuna, Pruriens, I think, is the herb. It's the active ingredient. Is L dopa. It's the precursor for dopamine. And so I think it has a lot to do whether you should push that, push that node hard or not. It has a lot to do with your snip status. And so there's a lot of snips related to this, genetic alterations that can push or pull that particular pathway. And like comp t is, is, is one of them, catechola methyl transferases, MTHFR, and another one is MTHFR, yeah, there's, there's tyrosine hydroxylase, another one. So that whether to push on that note or not is, I think, is, is really good if you're if you're trying to drive dopamine and and you have a snip and say comp T, that makes you on the side of less dopamine than normal. So I would say the compound that is the best at working in in that angle from our product would be the black cohosh, which stabilizes dopamine signaling. It's not pushing one way or the other. It's more like it's stabilizing in a known place in your hypothalamus. L dopa goes everywhere. I study l dopa dopamine production in the kidney, so it could actually make you your blood pressure drop too far, depending on your snip status and stuff. So I would say black cohosh does affect that pathway, but the if you respond well to to the L dopa product, that's great. Some some people, it makes them feel flat, flat, feeling lessened emotion. But, you know, it's a it's a safe thing to take and and if it helps, it helps you. You know, we're all about personalized medicine. How about it?
David Roberts 23:41
So another question, is there a downside to taking the menopause product before you've started perimenopause?
Dr. John Gildea 23:54
Sounds like the discussions we're having is whether you should take it if you're a male or not. We I went down that that pathway as hard as I could to try and get clarity, and I couldn't find any reason why a man wouldn't, wouldn't take it, won't have the same effects. But I think it answers the question of whether, before you have perimenopause, all the signals and things that are in it are generally good for you. So you don't have to wait until the noisy, noisy dopamine and serotonin, which is majority of the pathways that are going on in hypothalamus, and so when you're talking about the chaos at home, the thing that I kept thinking about was was one of the One of the common things that happens if you if your your relationship is is slightly broken, is understandable when you see the opposite of when you hug someone you love, you know that's oxytocin. And so that whole signaling goes up into your brain and works on micro. Clear. So a lot of the emotional things that happen when you're having conflict with your family is a thing called micro we got priming, and that's a that's a known defect that not defect. It's just a signaling node that is, is causes some brain chaos that doesn't feel real great. It's the opposite of how you feel really good. When you give a hug to someone you really love. A child recognizes you as not having destroyed them during their youth. Like get that at this point, and my kids are a little bit older, recognizing some of the things we did were positive. Yeah.
Dr. Martin Katz 25:43
I mean, GABA is also involved there. So serotonin, dopamine and GABA and again, just going for the balance, using these products, again, that are affecting our our hormones, the genes that are turned on, the misrepresentation of genes. And again, more alpha, I mean more beta versus alpha. And what's happening at the cell level can have a significant effect on on these, on the serotonin, dopamine and and Gavin. Again, cortisol certainly plays into this
David Roberts 26:18
great if. And again, listeners can type in questions into the chat or into the QA in your zoom, but we'll be continuing answering questions. So will the product interact with my thyroid medication, antidepressants or other supplements? Yeah.
Dr. Martin Katz 26:42
I mean, this is the million dollar question John and I dive down this. This question so very often, and it's, it's a very, very, very difficult question to answer based on on what's happening at the liver and what's happening at the cellular level to create, to sort of up regulate or block some of these enzymes that break break down anything in the body. So in order to clear something, you need a broken down through what's called phase one, and then you go through phase two. It's methylated or hydroxylated, and then you eliminate it. And you know, a lot of these products go through some of the same, same enzymes, and even within some of these phytonutrients, you see both inhibition and and turning on of these, of these enzymes. So it gets very, very tricky. You know, these are, these are foods we have not found, found significant evidence to show that there's a problem with medication, obviously, thyroid, you want to take half an hour before you eat for for good reason. Statins, you need to be a little careful. What were the other medications arrested about thyroid?
David Roberts 27:53
You thyroid, antidepressants or other substance?
Dr. Martin Katz 27:58
Yeah, I mean antidepressants again, go through liver metabolism. So you want to be a little careful, just sort of, there may be more more of the medication, but part of the supplement also metabolize it more quickly. So it seems to be a balance. I don't see any reason. Again, we'd have to specifically look at each one of the medications you're taking, and, and, and get an idea. It's very hard to fall in the literature. And can be, can be quite confusing, but for the most part, we're, we've looked at lot, a lot, a lot, a lot of phytonutrients, and have not found to be a problem.
Dr. John Gildea 28:34
Yeah, and sort of my and a good metric there would be, if you're taking a Mara mean oxidase inhibitor,
not so much anymore. Yeah. And then,
and then, for instance, take the take the L dopa product, that that's an enzyme that's specifically blocking the uptake of dopamine. You take L dopa, the precursor, it's going to have a reaction, and in that case, but modulating dopaminic, menergic, quick changes and hypothalamus is less likely, far as I can far as I can tell.
Dr. Martin Katz 29:11
And if you, if you generally have an issue with starting medicine, just start more slowly, at a lower dose, and slowly build maybe, if it's our supplement, you're starting maybe every other day, just monitor the symptoms, and then if you seem to be tolerating and start with one capsule maybe every other day, then go to every day one capsule, and then increase it to two, and just monitor how you're doing with those meds and how you feel.
David Roberts 29:33
And that actually piggybacks on another question, do I need to take the product every day, or can I just use it on my bad symptom days.
Dr. Martin Katz 29:44
Good question. Yeah, I would suggest, likely every day, just knowing the sort of physiology, the science of what's happening with progesterone and the and what's happening with it. So estrogen is, again, very complex. Where it's what receptor it's hitting, how it's being broken down, both in the liver, to two, four, it's Hydrox being hydroxylated to two, 416, and so again, part of our product really tries to shift that balance to to more, healthier hydroxylation, which would be two, again, it's trying to shift more to a beta receptor and so so long term, I think you're going to find more benefit if you're more consistent with it. So we can limit that build up of four or 16 hydroxylation or hitting the Alpha. I think you'll just be more happy with the overall symptom control, rather than sort of just hitting it here and there, and you sort of never know where you are. That's my take.
Dr. John Gildea 30:49
Yeah, it kind of seems like when I when I was thinking about when to push and when pull, it would be hard to be that aware of of your pushes and pulls right, because, you know, if you ate badly that day, you may not, you know, clear your glucose that you know by the time you go to sleep, that's going to affect how you sleep that night. That's a stressor. I mean, if, if you have a way of tracking, sort of, your total level of stress per day, that's going to be feeding these systems.
Dr. Martin Katz 31:23
Maybe you can, yeah, when you can look at HRV, but the question is, how accurate is HRV?
Dr. John Gildea 31:29
Yeah, and you were talking about GABA being one of the, one of the things here, that's, that's a known MP, not am kinase. What's the other end of GABA is there, it interacts with other brain related chemicals and and so in in, in one person's case, you have sympathetic dominance based on on SNPs, you can tell by personality types whether you're sympathetic dominant. And those type of people have to be more aware of, you know, being relaxed, being more contemplative, slowing down for when they eat they're gonna you're gonna just have a more, more difficult time going against, you know, you being anxious all the time. So people's basic settings are going to affect these pathways as well, and that's why you wouldn't just, you know, say, and at, a valium is would be perfect for this scenario. You know, some some people, you may have to have a valium if it gets bad enough.
Dr. Martin Katz 32:42
Vitamin V, yeah, we don't, we don't want too much volume in the system, especially as we age cognition unfolds, yeah,
Dr. John Gildea 32:50
and those are short term things for sure. Yeah, it does seem like it would be more beneficial to have a background stimulation of all those that you know, we have four big pathways that you're pushing for longevity, and that's gonna that's gonna make your transition into paramount and pause better if you do it more consistently
David Roberts 33:07
and similarly. Is the product safe for long term use, or should I cycle it
Dr. Martin Katz 33:15
certainly would be appropriate for long term use. Again. You know, I'm the owner of a supplement company, and I sometimes take break from a supplement based on how I'm feeling, what I'm doing, what else I'm pushing, pulling to get in, to get an idea yesterday, how often you forget, or how often I forget to take it. But I'm also monitoring the effects of other things I do to get a sense of how this is holistically helping me. So that's totally up to you, but there shouldn't be any reason not to do it long term, I agree,
Dr. John Gildea 33:47
unless it cures you of it, then maybe stop. Well, that's what we're hoping for.
David Roberts 33:53
Can I take the menopause product if I have MC a s histamine intolerance or a very sensitive system.
Dr. John Gildea 34:04
Man, good question. Is
Dr. Martin Katz 34:09
the MCAS mast cell activation syndrome? Yeah, anybody's wondering what MCAS is?
Dr. John Gildea 34:13
There's so many things that can drive that, you know, it's this whole if your gut system is DMI and it can drive that system. You can have a hyperactive nervous system associated with your gut system. Can be, you know, hypersensitive and pressure-sensitive. You can have low level sensitivities to foods. So, so complicated. It would really depend on why you have MCAS and
Dr. Martin Katz 34:43
right, that's where we would probably be going root, and certainly adding quercetin would be, yeah, good, slow first, for sure, very slow, yeah, this, this is a good place to go, slow at quercetin and think about doing certain i. A probiotics that may help with MCAS and histamine within the gut.
Dr. John Gildea 35:06
Yep, timing when you're eating and when you get the discomfort, you have a rough estimate of where, where your dysfunction is, if you know it's, you know, intestinally related. Or if you have SIBO, that's one of the drivers. If you have IBS C, IBS D, IBS M, you know, those are all connected with it. So, you know, getting it locked into to what you know you really have dictates a lot of what you're going to do and to get the best possibility of pushing in the right direction. Yeah.
Dr. Martin Katz 35:39
IBS C, just in case people are not irritable bowel syndrome, constipation or IBS, D, irritable bowel symptoms, diarrhea or M is mixed.
David Roberts 35:50
So another question, how does the resveratrol in your menopause product differ from red wine or generic resveratrol supplements. Yeah.
Dr. John Gildea 36:05
So regular resveratrol is pretty short lived inside the bloodstream, and so it's inactivated before it gets to distant tissue. And so we worked hard to try and get it to circulate for a longer period of time. And the evidence that that we achieved that was that if you take a regular resveratrol supplement, even one that has more than 10 times as much as ours, we you don't see acute drops in blood sugar. But with with our resveratrol, within four hours, you see some deflection in blood sugar, which was the metric that we were using to formulate it to get it past the enterocytes and then into the circulation and lasting long enough so you're seeing actual physiology that you will not see even With up to a gram of resveratrol. That's just plain resveratrol.
David Roberts 37:05
And is it helpful if you are already in menopause and on
Dr. Martin Katz 37:12
hrts, and on hrts, this would be a great reason to start. And if you're not on hrts, obviously you you want to be very careful with hrts, if you've had menopause for years, and then you start hormone replacement therapy, and there's different ways of doing that. But again, the earlier you start HRT with perimenopause or menopause, the better, again, based on symptoms and going from there, but I don't see any reason. Again, this is so complex at the hormone at the hormonal level, it's complex at the membrane level, the nuclear level, the cell membrane level, how you're breaking down estrogen, how much estrone versus estradiol you have, estradiol being the much more potent form of estrogen, which you lose and and get conversion to estrogen type one or estrone. Again, when you're breaking these down, is it not to keep saying the same thing is two, 416, hydroxylation, which can have an effect, and our product would tend to push you, not tend to our product would push you in the right direction of having those so there wouldn't be any reason not to to to take our product.
Dr. John Gildea 38:26
Yeah, it's probably a good place to bring in the one of the factors that we haven't talked about yet is steroid hormone binding protein, and so it carries around testosterone and estrogens. And you can, you can, you can check it in your bloodstream as well. Yeah, I was gonna say this is it's solidly in a in a personalized medicine world, because if your steroid hormone binding, Globe binding globulin is is very low, then you have to sneak up on to the HRT. And then do you need small amounts of testosterone as well in order to get everything really balanced? And so at the start of doing that, getting a Dutch test, and then after taking it for a while, getting it retested, just seems like a really good strategy. And I would say the for sure that carnostic acid is pushing everything in the right way, depending on the level of adiposity as well, because a person is quite overweight, whatever testosterone around is around will be being converted to estrogen. And so that's going to change things too, so that that it can be answered. I think there was a way to sneak up on doing HRT really well with the support of these metabolic handles and happy hypothalamus is always helpful, in general,
Dr. Martin Katz 39:55
yeah, and the same is true of two higher sex hormone bonding globulin. So this will push. Right direction.
David Roberts 40:03
If you said that the menopause product helps with blood sugar and belly fat, is it overkill to take it with your GL, perfect.
Dr. John Gildea 40:16
Wow, that's a perfect question.
Mean, they teed it up for you? John, yeah, it's like 121212
so if the carnostic acid is number two for all three of those, NRF two, NF, kappa, B and amp kinase, and they're by different mechanisms. So sulforaphane is, you know, our general product. That's the best NRF two inducer around. We think that everybody should be on that. So I'll answer beyond GL perfect is the next one is Berberine. Berberine is, is a is the best inducer of AMP kinase. So it would work, work with that. Probably have to watch your your blood sugars at that point. You want to at least make sure that you can get too fast to drop and blood glucose, where you feel lower RO, and it's approaching that territory. But, you know, do it. Do it smartly again. Start slow. If you're going to do a gel perfect on top of this one, I would, I would sneak up onto it, and then agcg kind of has a lot of the handles that are, are different than, than what we talked about today, or bird brain. And I guess Alpha, Alpha Lipoic Acid is the driving the glucose sink into your muscles, so that glute four loading of your muscle is, is there's, I don't see any. I don't see any reason not to take both of them, except that you're getting into territory where you're getting those three or four handles pushed harder than has been studied.
Dr. Martin Katz 41:55
Yeah, and remember, exercise doesn't even need glued for it just goes into the cell with actually gets glucose into the cell through, certainly through glute four, but also just based on exercise and need of cell. So the strongest there, as you know, I like exercise, is exercise.
David Roberts 42:13
Yeah, and we are coming down to the last question. If you have any questions, feel free to type them in the chat or the Q and A box, and you can actually ask question about a different supplement than the menopause supplement, if you have one.
Dr. Martin Katz 42:31
But again, just David as you're thinking about that last question. Just please ask questions, because this is a really important part of your life. This transition is really important, it's good to feel good. A lot of people in years past, and certainly continuing, if you're having mood swings and anxiety and depression will again blame, you know, a neurotic sort of baseline or woman, and put you on antidepressants or anti anxieties, where we need to certainly address this hormonal change. If you're starting to have more frequent UTIs, the health of the vagina is also very important, and there's things that we can do to maintain that health. And so if you're noticing an increase in in UTIs, please also ask your physician for some guidance there. Great.
Dr. John Gildea 43:24
I'm just happy no one said, is HRT good for all people. Oh, I was gonna ask that Dodge did.
Dr. Martin Katz 43:30
Well, there you go. You haven't, because you just brought it up.
Dr. John Gildea 43:33
But it is one of those things that that it's a current topic that is being that is being investigated, where, in a number of model, organisms actually taking estrogen in by males is showing increases in longevity. So we're, we're, we're betting on the fact that that's a big part of that is er beta agonist. And so we think taking resveratrol for sure, as a as a male, is good for you. And so the the whole is, estrogen always, is estrogen always good for all people. Is, is, I'm going to leave that up for someone else that has to prescribe it. Yeah.
Dr. Martin Katz 44:18
Again, you know, a Dutch test can tell us a lot of things. And certainly, if you're just pushing estrogen, estradiol, cream or vaginal trash or ring or whatever, and you're not monitoring the effects, you got to be really careful again, where, where is what nuclear receptor Are you hitting? How hard are you hitting the cell? Are you getting 16 hyper proliferation, which would be a negative thing, or four hydroxylation, again, negative versus a two? I think these things are very important to figure out before you just across the board, prescribe HRT, and then there's going to be some woman who have, you know, the genetic. A wild card, and, you know, probably won't have much in life. Symptoms have been really addressing their lifestyle appropriately, and are lucky enough to have all the right genes and receptors, and they probably don't need anything either. So I don't think it's for everybody, but, but certainly can be helpful as we age, if we're doing it very responsibly and personalized. I think, is extremely important.
Dr. John Gildea 45:23
Think a lot of people that are are taking our broccoli product are getting estrogen like effects because of the estrogen metabolism. You know, the quinolation estrogens are quinolated, and so broccoli induces nq, oh, one, which is, you know, unquenching. So it's, it's, it's actually pushing in the right way. A youthifying version of
Dr. Martin Katz 45:48
you ever heard that word? We just might have heard that we're, we're here for the first time. It's a great word that is awesome. I've never heard of you the fine. You heard it here first, thing
Dr. John Gildea 46:00
is, but in that metabolism of estrogen can, can, can help a lot of things. And, I mean, it wouldn't, wouldn't be a bad idea to think about trying to decrease your inflammation, decrease, you know, increase your nqo one before you go into hrts. You know, some of those symptoms that you might be having, how you're metabolizing estrogen, which I think is the point you're you've made a couple of times
David Roberts 46:23
more than more than once, probably, like five times. And so this, this question actually is relevant. If broccoli, it helps to detox estrogen, should people stop taking it once they start to lose estrogen? What would it? Would it be counterintuitive to take both the menopause product and broccoli? Yeah.
Dr. Martin Katz 46:40
So again, this is pushing the needle in the right direction versus the wrong direction. So how are you methylating? So this phase two is very, very important there. If you do happen to have phase one, where you're you're more on the 416, hydroxylation, the Phase two will help take care of that and clear those molecules. Two is going to broccoli will help push towards two with less inflammation, oxidative stress, and then again, have have that normal phase two detoxification and interface three. So I do think broccoli can be quite helpful in this case, and certainly in Q 01, you know, again, one of my favorite words, broccoli, being such a pleiotropic molecule helps in so many ways with this NRF two, and hitting the nucleus in such a hard way with so many antioxidant genes anti inflammation that it's can be quite beneficial.
Dr. John Gildea 47:40
Yeah, we can kind of go back to old conversations that we had when we went to a conference. There were so many people asking questions about glutathione GST, and so that's another one of those connection points where, how you, how you there's a lot of people that have SNPs in these glutathione transferases, you know for whether that system of detoxification works well for a lot of people that have those s you can through sulforaphane and do a number of GST enzymes so that you can have another enzyme take up some of the slack of ones that you have a snip in and then in this, in the same way, you'd be a little bit remiss to say, What about supplementing that glutathione system? You know, some people take glutathione itself or NAC, so there's, there's good pushing, pushes for, for that, yeah, Glycine as well, especially in people that kind of have trouble sleeping, so that's no another one two punch. So there's a lot of good things that you can stack together to to push things in the right direction. Great.
David Roberts 48:51
Well, gentlemen, thank you for answering these questions and giving us the overview of the product, and thanks everyone for joining us today the as I mentioned at the beginning of the webinar, that the product will be coming out this week, hopefully sooner rather than later, but stay tuned and check your email. All right, thanks so much. This has been the Mara labs podcast. The views expressed should not be considered as medical advice. You should consult with a medical practitioner with any health questions or concerns you have you.
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