Sulforaphane + Curcumin Synergy: Better Together

At Mara Labs, we’re often asked: “Can I take sulforaphane and curcumin together?”

Not only can you - you should!

Emerging research and direct laboratory evidence show these two compounds don’t just complement each other; they act synergistically, working through overlapping and distinct molecular pathways to support inflammation resolution, detoxification, and cellular resilience.

The Science of Synergy: NRF2 + NF-κB Balance

Both sulforaphane (from broccoli sprouts) and curcumin (from turmeric) are phytochemicals with robust biological activity, but each has a distinct target:

• Sulforaphane is best known for activating the NRF2 pathway, a master switch for over 200 protective genes involved in detoxification, antioxidant production (like glutathione), and cellular defense.

• Curcumin is a powerful NF-κB inhibitor, meaning it helps turn down inflammatory signaling at the cellular level. See more info on our curcumin formulation here.

While sulforaphane also weakly inhibits NF-κB, and curcumin also moderately activates NRF2, neither compound fully activates both pathways on its own. But together?
“When you put those two together, both pathways are on completely,” explains Dr. John Gildea, cellular biologist and lead scientist at Mara Labs in a recent podcast. “That’s synergy.”

In our studies, the combination of sulforaphane and curcumin produced a stronger cellular response than either compound alone - even at concentrations too low to produce an effect independently. That’s the gold standard definition of strict synergy.

Here's a link to independent research on this as well.

What We’ve Seen in the Lab

In our cell culture models, combining sulforaphane with either curcumin or PEITC (a related compound from watercress) resulted in about 22–23% cell death in breast cancer cells—far greater than either compound alone. The synergy likely arises from dual pathway activation:

• - NRF2: Enhanced antioxidant defenses, detoxification enzymes (like ALDH), mitochondrial repair

• - NF-kB: Reduced inflammation and inflammatory cytokines

Interestingly, combining sulforaphane and berberine yielded an even higher synergy (~40% cell death), likely due to berberine’s unique activation of AMPK, a metabolic energy sensor. These layered benefits make each combination exciting—and worthy of future exploration.

The Study That Proved It

A 2009 study in Pharmaceutical Research tested sulforaphane and curcumin on immune cells producing inflammatory lipopolysaccharides (LPS). Researchers found:

• - The effect on pro-inflammatory markers (NF-κB) was additive

• - The effect on anti-inflammatory genes (NRF2 pathway) was synergistic

This supports what we’ve observed firsthand: when it comes to amplifying cellular defense, the combination is greater than the sum of its parts.

But There’s a Catch: Stability and Bioavailability Matter

Most supplements fall short. It’s not enough to take “sulforaphane” or “curcumin”—you need forms that are both stable and bioavailable:

• Sulforaphane’s Challenge: Sulforaphane is notoriously unstable. Most supplements contain only its precursor (glucoraphanin), which your body may or may not convert depending on gut health and enzyme availability. BrocElite® solves this by providing stabilized sulforaphane, PEITC for enhanced synergy, and naturally preserved isothiocyanates.

• Curcumin’s Challenge: Curcumin is fat-soluble and poorly absorbed. Many “highly bioavailable” products use synthetic emulsifiers like polysorbate 80. CurcElite® was developed after rigorous internal testing, outperforming other leading curcumin products by 21x in our fluorescence urine study. We also compared it to the top brands of curcumin currently on the market and here's what we found.

In this study, you can see the bioavailability of top curcumin brands. 

Then, we tested the metabolites in urine for the top brands compared to CurcElite:

Why We Created BrocElite® + CurcElite®

At Mara Labs, we don’t chase trends - we chase data.

Our sulforaphane is stabilized, bioactive, and tested for shelf-life potency. Our curcumin is highly bioavailable without synthetic emulsifiers. We study how they interact at the cellular level, not just in theory—but in practice.

For more on our approach, check out our science blog and podcast episodes.

Synergy in Real Life

The synergy between sulforaphane and curcumin isn’t just about cellular pathways. It’s about real-world outcomes:

• - Reduced inflammation → better mobility → more exercise

• - Increased NRF2 → better mitochondrial function → improved mood

• - Enhanced detox pathways → reduced toxic load → clearer thinking

As Dr. Gildea puts it, "You can look at synergy on the molecular level, but it also matters at the whole person level."

The Takeaway

If you’re looking to optimize your body’s ability to detox, reduce inflammation, and age resiliently, pairing sulforaphane and curcumin is one of the most science-backed strategies available. But make sure your supplements actually deliver:

✔️  Stabilized sulforaphane (not just broccoli powder)
✔️  Bioavailable curcumin (without synthetic fillers)
✔️  Tested synergy

That’s what we built BrocElite® and CurcElite® to do.

References

1. Surh, Y. J., Kundu, J. K., & Na, H. K. (2008). Synergistic effects of phytochemicals in cancer prevention. Cancer Letters, 269(2), 199–206. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/18462866/
2. Kensler, T. W., Wakabayashi, N., & Biswal, S. (2007). Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annual Review of Pharmacology and Toxicology, 47, 89-116. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/16968214/
3. Aggarwal, B. B., & Harikumar, K. B. (2009). Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. The International Journal of Biochemistry & Cell Biology, 41(1), 40-59. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/18662800/
4. Negrette-Guzmán, M., Huerta-Yepez, S., Tapia, E., & Pedraza-Chaverri, J. (2013). Modulation of mitochondrial functions by the indirect antioxidant sulforaphane: a seemingly contradictory dual role and an integrative hypothesis. Free Radical Biology and Medicine, 65, 1078-1089. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/24076121/
5. Bose, S., Panda, A. K., Mukherjee, S., & Sa, G. (2015). Curcumin and tumor immune-editing: resurrecting the immune system. Cell Division, 10, 6. PubMed Link: https://pubmed.ncbi.nlm.nih.gov/26425099/